ISG15 and ISGylation: Emergence in the cytoskeleton dynamic and tumor microenvironment

Cytoskeletal remodeling affects the shape, adhesion, and motility of cells. dynamics are modulated by matrix proteins, integrins, several cytokines in tumor microenvironment. In this scenario, signaling is activated integrins interferons, which can induce ISG15 gene expression. This encodes a ubiquitin-like protein that functions as modifier via ISGylation system. Furthermore, non-conjugated acts cytokine-like protein. viewpoint, interplay between free ISG15, ISGylation, cytoskeletal microenvironment discussed.